Clomi-Franil  10 – 25  (Film Coated Tablets)
                                                                         

Composition:
Each film coated tablet contains 10, or 25mg Clomipramine HCl.

Mechanism of Action:
Clomi-Franil is a tricyclic antidepressant and its pharmacological action includes alpha-adrenolytic, anticholinergic, anti-histaminic, and 5HT receptor blocking properties.

Indications:
Clomi-Franil is indicated for the treatment of:

  • Depressive cases.
  • Obsessional and phobic states.
  • As an adjunctive treatment of cataplexy associated with narcolepsy.

Dosage:
For the treatment of depressive cases: 

  • Adults: Initial dose 10mg daily, increased gradually to 30 – 150mg daily in divided doses through the day or as single dose at bed time. Higher doses may be needed in some patients.
  • Elderly: Initial dose 10mg daily, increased with caution under close supervision to a maximum of 30 – 75mg daily.

For the treatment of obsessional and phobic states:

  • Adults: Initial dose 10mg daily, increased gradually to 100 – 150mg daily.
  • Elderly and sensitive: Initial dose 10mg daily.

As an adjunctive treatment of cataplexy associated with narcolepsy: 10 – 75mg daily.

Side Effects:
Drowsiness, dryness of the mouth, constipation, orthostatic hypotension, tachycardia, palpitations, allergic skin reactions and pruritus.

Contraindications:
Hypersensitivity to the drug, or cross-sensitivity to tricyclic antidepressants of the dibenzazepine group. Recent myocardial infarction, heart block, mania, severe hepatic disease, retention of urine, narrow angle glaucoma, and concomitant use with MAO inhibitor (or within 3weeks before or after treatment with MAO inhibitor).

Drug Interactions:
It should be left 3 weeks at least between the treatment of the drug and monoamine oxidase inhibitors. The drug should not be given with sympathomimetic agent such as: Adrenaline, ephedrine, and phenylephrine including nasal drops. Side effects may be enhanced by the concurrent administration of C.N.S depressants such as: Alcohol, anti-muscarinic agents, and barbiturates. Cimetidine, calcium channel blockers may increase the plasma concentrations of the drug and toxicity.

Precautions:

  • Before initiating treatment it is advisable to check the patient’s blood pressure, because individuals with hypotension or a labile circulation may react to the drug with a fall in blood pressure.
  • It is advisable to monitor cardiac and hepatic function during long term therapy with the drug.
  • The drug should be withdrawn gradually to reduce the risk of withdrawal symptoms.

Use in Pregnancy or Lactation:
It should not be used especially during the first and last trimesters. Nursing mother should be advised to withdraw the medication, or cease breast-feeding.

Presentation:
Carton pack contains 2 blisters of 10 film coated tablets in each, with leaflet.

 

 
 
 

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