CLONA-RIL   (TABLETS / ORAL DROPS)

COMPOSITION:
Each tablet contains 0.5, 1, or 2mg Clonazepam.
Each 1ml oral drops contains 2.5mg Clonazepam.

INDICATIONS:
CLONA- RIL is used in all clinical forms of epileptic disease and seizures in infants, children and adults, especially petit mal or grand mal.

DOSAGE AND ADMINISTRATION:
The dosage of CLONA-RIL must be adjusted to the needs of each individual and depends on the individual response to therapy. Treatment should be started with low doses. The dose may be increased progressively until the maintenance dose suited to the individual patient has been found. The total dose may be given at night for the first four days of treatment.


Age

Initial dose

Maintenance dose

Infants

Not exceed 0.25mg daily
Or 0.1ml

0.5 – 1 mg daily
Or 0.2 – 0.4ml

Children 1 – 5 years

Not exceed 0.25mg daily
Or 0.1ml

1 – 3 mg daily
Or 0.4 – 1.2ml

Children 5 – 12 years

Not exceed 0.5mg daily
Or 0.2ml

3 – 6 mg daily
Or 1.2 – 2.4ml

Adults

Not exceed 1mg daily

4 – 8 mg daily

Elderly

Not exceed 0.5mg daily

Individual

The daily dosages, which are mentioned above should be divided into 3 – 4 doses. If necessary, larger doses may be given as instructed by physician.
Note that the elderly are particularly sensitive to effects of central depressant drugs and may experience confusion.
As with all other antiepileptic drugs, treatment with drug, even of short duration, must not be abruptly interrupted, but must be withdrawn by gradually reducing the dose.

SIDE EFFECTS:
Fatigue, somnolence, and occasional muscular hypotonia. Such effects are usually transitory and disappear spontaneously as treatment continues or with dosage reduction.

CONTRAINDICATIONS:
Sensitivity to benzodiazepines, acute pulmonary insufficiency; respiratory depression.

DRUG INTERACTIONS:
When CLONA- RIL is used in conjunction with antiepileptic drug, side effects and toxicity may be more evident particularly with hydantoins or phenobarbitone. Known inhibitors of hepatic enzymes such as cimetidine, reduce the clearance of benzodiazepines and may potentiate their action. Known inducers of hepatic enzymes such as rifampicin, may increase the clearance of benzodiazepines.

PRECAUTIONS:

  1. Dosage should be reduced in patients with chronic pulmonary insufficiency, or with impairment of renal or hepatic function, and elderly.
  2. Since alcohol can provoke epileptic seizures, patients should be advised not to drink alcohol during treatment.
  3. Patients should be warned of the possible hazard of driving or operating machinery.
  4. Prolonged administration of drug may cause habituation.

USE DURING PREGNANCY OR LACTATION:
The use of drug during pregnancy or lactation should be avoided unless there are compelling reasons.

PRESENTATION:
CLONA-RIL Tablets: Carton pack contains bottle of 20 tablets of 0.5, 1, or 2mg, with leaflet.
CLONA-RIL Oral Drops: Carton pack contains bottle of 60ml with a measuring gauge, and leaflet.

 
 
 

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