Do-Spertine   (Syrup)
Antiemetic

Composition:
Each 5ml Syrup contains 5mg Metoclopramide HCl.

Mechanism of Action:
Do-Spertine possesses parasympathomimetic activity as well as being a dopamine receptor antagonist with a direct effect on the chemoreceptor trigger zone. Do-Spertine stimulates the motility of the pyloric and gastrointestinal tract, without affecting gastric acid, bili and pancreas secretion. Do-Spertine increases tissue sensitivity to acetylcholine. Do-Spertine has a sedative effect like phenothiazine.

Indications:
Do-Spertine is indicated for:

  • The relief of upper gastrointestinal symptoms including heartburn, nausea, vomiting, inflation and dyspepsia.
  • Gastritis and duodenitis associated with gastrointestinal disorders including peptic ulcers and sequelae gastroectomy.
  • Esophagus distention (diaphragmatic hernia).
  • Nausea and vomiting by migraine.
  • Nausea and vomiting which is associated with contraction of gall bladder.
  • Do-Spertine may be used to facilitate gastric emptying during radiographic examinations.
  • It is also used in the treatment of nausea and vomiting associated with cancer therapy.
  • Do-Spertine could be given in doses of 10 ml before surgery for preventing nausea and vomiting.

Dosage:
Children: 5 ml three times daily.
Adults: 10 ml three times daily.
Or as directed by a physician.

Contraindications:
Do-Spertine should not be used in intestinal obstruction or immediately after surgery. Do-Spertine should not be given to patients with pheochromocytoma.

Side Effects:
Do-Spertine is well tolerated. Do-Spertine may cause extrapyramidal symptoms at high doses, especially in children. Other adverse effects include: Restlessness, drowsiness, dizziness and bowel upsets such as diarrhea or constipation.
Do-Spertine increase prolactin secretion in doses 10 – 15ml three times daily. On the contrary in doses of 5mg three times daily it does not have this effect.

Precautions:
Care should be exercised in epileptic patients and patients being treated with other centrally acting drugs.

Use During Pregnancy and Lactaion:
Metoclopramide should only be used during pregnancy when there are compelling reasons and is not advised during the first trimester.
Metoclopramide is found in breast milk, therefore it should not be used during lactation

Presentation:
Carton pack contains glass bottle of 100ml, with leaflet

 

 

 
 
 

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