Pizofen (Tablets – Syrup)

               
COMPOSITION:
Each 10ml Syrup or tablet contains 0.725mg pizotifen malate, equivalent to 0.5mg pizotifen base.

MECHANISM OF ACTION:
Pizofen has anti-serotonin and anti-tryptaminic properties, anti-histaminic effect and antagonistic activity against kinins. It also has a sedative and appetite stimulating properties. Pizofen has prophylactic effect in migraine.

INDICATIONS:
Prophylactic treatment of recurrent vascular headache, including common migraine, neural migraine. It should not be used during acute attack.
It is also used as an appetite stimulant.

DOSAGE AND ADMINISTRATION:

  • Prophylactic treatment of migraine:

Children: up to 1.5mg daily (30ml Syrup or 3 Tablets) divided into three doses, or 1mg daily as a single dose at night (20ml Syrup or 2 Tablets).
Adults: 1.5mg daily (30ml Syrup or 3 Tablets). It can be taken as a single dose at night or in three divided doses, each of 0.5 mg (10ml Syrup or 1 Tablet). Dosage should be adjusted to the requirement of individual patients, up to a maximum of 4.5mg daily (90ml Syrup or 9 Tablets). Or up to 3 mg (60ml Syrup or 6 Tablets) may be given as single dose daily.

  • As an appetite stimulant: It should be taken before the meal.

Children: 0.025 mg/kg.
2 – 6 years: 5 – 10ml daily, 2 – 3 divided doses.
6 – 12 years: 10 – 20ml daily, 2 – 3 divided doses.
Adults: To start with 0.5mg daily (10ml Syrup or 1 Tablet), to be gradually increased to 1.5mg daily (30ml Syrup or 3 Tablets).
(Each 1 tablespoonful = 5ml of syrup)

CONTRAINDICATIONS:
Hypersensitivity to the drug.

SIDE EFFECTS:
Drowsiness is more common, rarely may occur: Dizziness, dry mouth, nausea, constipation, Pizofen affects normal reaction of the body, a central sedative effect, and increasing body weight and appetite.

DRUG INTERACTIONS:
It increases the effect of hypnotics, sedatives, and alcohol.

PRECAUTIONS:
Caution is required in the presence of closed angle glaucoma, in patients with a predisposition to urinary retention and when driving machinery or cars. Dosage adjustment may be necessary in patients with kidney insufficiency.

USE IN PREGNANCY OR LACTATION:
It is not recommended to use during pregnancy or lactation.

PRESENTATION:
Carton pack contains 2 blisters each of 10 tablets or glass bottle of 200ml, with leaflet.

 

 

 
 
 

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