TIZANID (Tablets)

Centrally Acting Skeletal Muscle Relaxant

 

Composition:
Each tablet contains 2.288, 4.576, or 6.864mg Tizanidine Hcl, equivalent to 2, 4, or 6 mg Tizanidine Base.

Mechanism of Action:
TIZANID principal site of action is in the spinal cord. It preferentially inhibits polysynaptic mechanisms responsible for excessive muscle tone, mainly by restricting the release of excitatory amino acids from the interneurons of the spinal cord. It does not affect neuromuscular transmission.

Indications:
TIZANID is indicated for:

Painful muscle spasms which are associated with postural, functional disorders of the spine (cervical and lumbar syndromes), following surgery for example for herniated intervertebral disc, or for osteoarthritis of the hip

Spasticity due to multiple sclerosis, diseases of the spinal cord such as chronic myopathy.

Muscle spasms and spasticity due to neurological disorder, (for example following cerebrovascular accident or head injury), or due to infantile cerebral palsy.

Dosage:

Treatment of painful muscle spasms: 2–4mg 3 times daily. In severe cases an extra dose of 2 or 4 mg may be taken at night.

Treatment of Spasticity: The dosage should be adjusted to the needs of the individual patient among these limits:

Initial dose: Not exceed 6 mg daily divided into 3 doses. It may be increased stepwise by 2–4 mg at 4–7 days intervals.
Optimum therapeutic response: 12–24mg daily divided into 3–4 equally spaced doses.
Maximum dose: Not exceeded 36mg daily.

Side Effects:
TIZANID is well tolerated. With low doses, as recommended for the relief of painful muscle spasms, side effects are rare and usually mild and transient. They include drowsiness, muscle weakness, fatigue, dizziness, dry mouth, nausea, and slight reduction in blood pressure. With higher doses, as recommended in spasticity, the above side effects are more frequent and more pronounced but seldom so strong enough to require discontinuation of treatment. In a few patients it may cause insomnia, instance of hypotension, bradycardia, and transient increases in serum transaminases.

Contraindications:
Hypersensitivity to the drug.

Drug Interactions:
Concomitant use of TIZANID with antihypertensives (including diuretics) may occasionally cause hypotension and bradycardia. TIZANID may potentiate the effects of alcohol and sedatives.

Precautions:

  1. In patients with impaired kidney or liver function, the dosage should be adjusted as necessary.
  2. Patients experiencing drowsiness at the beginning of treatment should be advised not to drive or operate machinery.

Use in Pregnancy or Lactation:
The safety of using the drug in pregnancy has not yet been established. Therefore it should be used during pregnancy only if the potential benefit justified the potential risk.
Don’t use the product during lactation.

Presentation:
Carton pack contains 2 blisters each of 10 tablets, with leaflet.

 

 

 
 
 

© 2010 Domina Pharmaceuticals