Each 10ml Syrup contains 0.725mg pizotifen malate, equivalent to 0.5mg pizotifen base.
MECHANISM OF ACTION:
Pizofen has anti-serotonin and anti-tryptaminic properties, anti-histaminic effect and antagonistic activity against kinins. It also has a sedative and appetite stimulating properties. Pizofen has prophylactic effect in migraine.
Prophylactic treatment of recurrent vascular headache, including common migraine, neural migraine. It should not be used during acute attack. It is also used as an appetite stimulating.
DOSAGE AND ADMINISTRATION:
• Prophylactic treatment of migraine:
Children: up to 1.5mg daily (30ml Syrup) divided into three doses, or 1mg daily as a single dose at night (20ml Syrup ).
Adults: 1.5mg daily (30ml Syrup ). It can be taken as a single dose at night or in three divided doses, each of 0.5 mg (10ml Syrup). Dosage should be adjusted to the requirement of individual patients, up to a maximum of 4.5mg daily (90ml Syrup ). Or up to 3 mg (60ml Syrup) may be given as single dose daily.
• As an appetite stimulant: It should be taken before the meal.
Children: 0.025 mg/kg.
2 – 6 years: 5 – 10ml daily, 2 – 3 divided doses.
6 – 12 years: 10 – 20ml daily, 2 – 3 divided doses.
Adults: To start with 0.5mg daily (10ml Syrup), to be gradually increased to 1.5mg daily (30ml Syrup).
Hypersensitivity to the drug.
Drowsiness is more common, rarely may occur: Dizziness, dry mouth, nausea, constipation, Pizofen affects normal reaction of the body, a central sedative effect, and increasing body weight and appetite.
It increases the effect of hypnotics, sedatives, and alcohol.
Caution is required in the presence of closed angle glaucoma, in patients with a predisposition to urinary retention and when driving machinery or cars. Dosage adjustment may be necessary in patients with kidney insufficiency.
USE IN PREGNANCY OR LACTATION:
It is not recommended to use during pregnancy or lactation.