Each 1g gel contains 12mg Clindamycin phosphate (equivalent to 10mg clindamycin base), and 0.25mg Tretinoin
Glycerin, Carbomer, methylparaben, propylparaben, edentate sodium, anhydrous citric acid, purified water
Mechanism of Action:
Clindamycin: Antibacterial agent that binds to the 50S ribosomal subunits of susceptible bacteria and prevents elongation of peptide chains by interfering with peptidyl transfer, thereby suppressing protein synthesis; reduces surface fatty acids on skin; exact mechanism of action in treating acne unknown.
Tretinoin: Exact mechanism unknown; appears to cohesiveness of follicular epithelial cells with decrease microcomedo formation; also increases turnover of follicular cells to cause extrusion of comedones
Gel is used to treat severe nodular acne in adults and children who are at least 12 years old.
Emergency medical help should be taken if patient have any of these signs of an allergic reaction to Acne-gel: hives, difficult breathing; swelling of your face, lips, tongue, or throat.
This medicine should be stopped and call the doctor at once if patient has:
Common -gel side effects may include:
Before using the Gel, the patient should tell the doctor if he has: any allergies, a history of stomach or intestinal disorders
Pregnancy and lactation:
Pregnancy category C: It is not known whether Gel will harm an unborn baby. Tell the doctor if the patient is pregnant or plan to become pregnant while using this medication.
Breast-feeding: It is not known whether clindamycin and tretinoin topical passes into breast milk or if it could harm a nursing baby. Breast-feed should be avoided while using this medicine.
It is not likely that other drugs taken orally or by injection will have an effect on topically applied clindamycin and tretinoin. However, many drugs can interact with each other. The doctor should be told about all medicines patient use, including prescription and over-the-counter medicines, vitamins, and herbal products.
Dosage and Administration:
The Gel should be used exactly as the doctor has prescribed it for patient. It should not be used in larger or smaller amounts or for longer than recommended.
The hands should be washed before and after applying this medication.
The face should be washed with a mild soap or cleanser and the skin patted dry with a clean towel.
Only a pea-sized amount of gel should be Used and Applied to the entire face every night at bedtime.
The face should not be washed more than 3 times daily while using this medication, Washing more often or scrubbing the face when patient wash it can make the acne worse.