Composition:

Each enteric coated tablet contains 75mg Acetyl Salicylic Acid (Aspirin).

Indications:     

Aspirin75 has an anti-thrombotic action, mediated through inhibition of platelet activation, which has been shown to be useful in secondary prophylaxic following myocardial infraction and in patients with unstable angina or cerebral transient ischaemic attacks. Aspirin75 is indicated, where ever prolonged dosage of aspirin is required. The special coating resists dissolution in gastric juice, but will dissolve readily in the relatively less acid environment of the duodenum.

Dosage:

Children: Not recommended.

Adults for Anti-thrombotic Action: 150mg daily at diagnosis, and 75mg daily thereafter.

Side Effects:

It may induce hypersensitivity, asthma, Urate kidney stones, chronic gastro- intestinal blood loss, tinnitus, nausea and vomiting. The special coating of Aspirin helps to reduce the incidence of side- effects resulting from gastro irritation. It may also precipitate bronchospasm or induce attacks of asthma on susceptible subjects. 

ContraIndications:

Hypersensitivity to the drug, hypo-prothrombin anemia, haemophilia and active peptic ulceration.

DrugInteractions:

It may enhance the effect of anti-coagulants, oral hypoglycaemic agents, phenytoin and sodium valproate. It inhibits the uricosuric effect of probenecid and may increase the toxicity of sulphonamides.

Precautions:

• It should not be given to children, particularly those under 12 years.
• It should be used with caution in patients with a history of peptic ulceration or coagulation abnormalities, impaired renal function, hepatic function (avoid if severe), or in patients who are dehydrated.
• Patients using the drug should be advised against ingesting anti-acids simultaneously, to avoid premature drug release.
• In large doses, aspirin may also decrease insulin requirement.
• Patients with hypertension should be carefully monitored.

Use in Pregnancy and Lactation:

It should be avoided during the last 3 months of pregnancy. It should not be taken by patients who are breast- feeding, as it i