COMPOSITION:

Each 5ml Syrup contains 57mg Diprophylline.

INDICATIONS:

Diprophylline is theophylline derivative and has its effects.

It is better tolerated by mouth. Euphillin relaxes smooth muscle and relieves broncho-spasm. Euphyllin syrup is indicated mainly due to its dilating ‎and bronchospasmolytic effects in the following:‎

• Allergic asthma, pulmonary edema and pneumonitis.
• Acute infection of respiratory tract.
• The pulmonary disorders due to cardiac dysfunction.
• Chronic cases of asthma as a preventive measurement to avoid or prevent asthmatic seizures during day and night.

DOSAGE:

Infants: 5 mg / kg weight, 3 times daily.

Children: 1 tablespoon, 3 times daily.

Adults: 2 tablespoons, 3 times daily.

Or otherwise as instructed by physician.

SIDE-EFFECTS:

Central nervous system stimulation, palpitation, restlessness, vertigo, insomnia, headache and nausea, may occur.

CONTRA-INDICATIONS:

It should be given with caution to patients with hyperthyroidism, hypertension, cardiac arrhythmias, hepatic dysfunction, fever and renal failure. Concomitant use with other xanthine medications should be avoided.

DRUG-INTERACTIONS:

Propranolol, cimetidine, atropine, erythromycin and some other macrolides antibiotics may result in decreased clearance and increased serum half-life. Phenytoin and some other anticonvulsants as well as smoking may increase diprophylline clearance necessitating an increase in dose or dose frequency.

ABSORPTION:

Euphillin is rapidly absorbed from gastric mucosa and is largely excreted unchanged in the urine with an elimination half-life of approximately two hours.