Each 5ml Syrup contains 57mg Diprophylline.
Diprophylline is theophylline derivative and has its effects.
It is better tolerated by mouth. Euphillin relaxes smooth muscle and relieves broncho-spasm. Euphyllin syrup is indicated mainly due to its dilating and bronchospasmolytic effects in the following:
Infants: 5 mg / kg weight, 3 times daily.
Children: 1 tablespoon, 3 times daily.
Adults: 2 tablespoons, 3 times daily.
Or otherwise as instructed by physician.
Central nervous system stimulation, palpitation, restlessness, vertigo, insomnia, headache and nausea, may occur.
It should be given with caution to patients with hyperthyroidism, hypertension, cardiac arrhythmias, hepatic dysfunction, fever and renal failure. Concomitant use with other xanthine medications should be avoided.
Propranolol, cimetidine, atropine, erythromycin and some other macrolides antibiotics may result in decreased clearance and increased serum half-life. Phenytoin and some other anticonvulsants as well as smoking may increase diprophylline clearance necessitating an increase in dose or dose frequency.
Euphillin is rapidly absorbed from gastric mucosa and is largely excreted unchanged in the urine with an elimination half-life of approximately two hours.