Composition:

Each Film coated tablet contains 40 or 60 mg Alverine Citrate

Coating:

Pharmacoat, Poly Ethylene Glycol, Titan oxide, Isopropanol, Purified water

Pharmacodynamic properties

Alverine citrate is an antispasmodic with a direct action on smooth muscle.

Alverine citrate is a spasmolytic, which has a specific action on the smooth muscle of the alimentary tract and uterus, without affecting the heart, blood vessels and tracheal muscle at therapeutic doses.

Pharmacokinetics:

After oral administration, Alverine citrate is rapidly converted to its primary active metabolite, which is then further converted to two secondary metabolites. There is a high renal clearance of all metabolites indicating that they are eliminated by active renal secretion. The peak plasma level of the most active metabolite occurs between 1 and ½ hours after oral dosing

INDICATIONS:

• Irritable Bowel Syndrome
• Bowel movement disturbances caused by small sacs or pouches in the wall of the gut (diverticular disease).
• Abdominal pain associated with menstrual periods (Primary dysmenorrhea)
• Relief of other conditions associated with spasm of involuntary muscle.

CONTRAINDICATIONS:

Paralytic ileus or known hypersensitivity to any of the ingredients.

ADVERSE REACTIONS:

Possible side effects may include nausea, headache, dizziness, itching, rash and allergic reactions.

DRUG  INTERACTIONS:

There are no interactions reported with this medicine.

WARNINGS and PRECAUTIONS:

Child under 12 years: Not recommended.

Pregnancy & lactation:

Although no teratogenic effects have been reported, use during pregnancy or lactation is not recommended as evidence of safety in preclinical studies is limited.

DOSAGE and ADMINISTRATION:

Adult: 60-120 mg 1-3 times daily.