Each film coated tablet contains 10mg Clomipramine HCl.
Each film coated tablet contains 25mg Clomipramine HCl.
Mechanism of Action:
Clomi-Franil is a tricyclic antidepressant and its pharmacological action includes alpha-adrenolytic, anticholinergic, anti-histaminic, and 5HT receptor blocking properties.
Clomi-Franil is indicated for the treatment of:
For the treatment of depressive cases:
For the treatment of obsessional and phobic states:
As an adjunctive treatment of cataplexy associated with narcolepsy: 10 – 75mg daily.
Side - Effects:
Drowsiness, dryness of the mouth, constipation, orthostatic hypotension, tachycardia, palpitations, allergic skin reactions and pruritis.
Contra - Indications:
Hypersensitivity to the drug, or cross-sensitivity to tricyclic antidepressants of the dibenzazepine group. Recent myocardial infarction, heart block, mania, severe hepatic disease, retention of urine, narrow angle glaucoma, and concomitant use with MAO Inhibitor(or within 3 weeks before or after treatment with MAO Inhibitors).
Drug - Interactions:
It should be left 3 weeks at least between the treatment of the drug and monoamine oxidase inhibitors. The drug should not be given with sympathomimetic agent such as: Adrenaline, ephedrine, and phenylephrine including nasal drops. Side effects may be enhanced by the concurrent administration of C.N.S depressants such as: Alcohol, antimuscarinic agents, and barbiturates. Cimetidine, calcium channel blockers may increase the plasma concentrations of the drug and toxicity.
Use in Pregnancy or Lactation:
It should not be used especially during the first and last trimesters. Nursing mother should be advised to withdraw the medication, or cease breast-feeding.