Each 100g cream contains 1g Hydrocortisone.
Mechanism of Action:
Hydrocortisone is an anti-inflammatory steroid. Its anti-inflammatory action is due to reduction in the vascular component of the inflammatory
response and reduction in the formation of inflammatory fluid and cellular exudates. The granulation reaction is also decreased due to the
inhibition effect of Hydrocortisone on connective tissue.
Stabilisation of most cell granules and lysomal membranes decreases the mediators involved in inflammatory response and reduces release of
enzymes in prostaglandin synthesis. The vasoconstrictor action of Hydrocortisone may also contribute to its anti-inflammatory activity
Hydrocortisone Domina has topical anti-inflammatory activity of value in the treatment of irritant dermatitis, contact allergic
dermatitis, insect bite reactions and mild to moderate eczema.
Use sparingly over a small area once or twice a day for a maximum period of one week. If the condition has not improved, or worsens, consult your doctor.
This product should not be recommended for use on children under 10 years of age without medical advice.
Hydrocortisone preparations are usually well tolerated, but if any signs of hypersensitivity appear, application should stop immediately.
- Bacterial, viral or fungal infections of the skin.
- Hypersensitivity to the active substance or to any of the excipients.
- Use on the eyes and face, Ano-genital region, Broken or infected skin including cold sores, acne and athlete's foot.
Absorption: Topically applied steroids are absorbed to a significant extent only if applied to broken skin, to very large areas, or under occlusive dressings.
Distribution: Corticosteroids are rapidly distributed to all body tissues. They cross the placenta and may be excreted in small amounts in breast
Metabolism: Hydrocortisone is metabolised mainly in the liver, but also the kidney, to various degraded and hydrogenated forms such as tetrahydrocortisone.
Elimination: Hydrocortisone is excreted in the urine, mostly conjugated as glucuronides. Only very small amounts of unchanged hydrocortisone
Use in Pregnancy or Lactation:
- There is inadequate evidence of safety in human pregnancy. There
may therefore be a very small risk of such effects in the human foetus.
- There is no evidence against use in lactating women. However, caution should be exercised when Hydrocortisone Cream is administered to