Biso - Bloc

Biso - Bloc


Each film coated tablet contains 2.5, 5 or 10mg Bisoprolol Fumarate.

Mechanism of Action:

Biso-Bloc is a potent, highly β1-selective blocking agent. It depresses plasma renin activity, which leads to capillary dilatation. The blockade of β1-receptors, reduces heart action, and thus reduces oxygen demand. Biso-Bloc is effective in eliminating or reducing the symptoms of angina pectoris.


Biso-Bloc is indicated for the management of hypertension, angina pectoris.


The usual dose is 10mg once daily. The maximum recommended dose is 20mg daily. In some patients 5mg daily may be adequate, especially in elderly. In patients with final stage of renal or liver impairment, the dose should not exceed 10mg once daily.

To retain selectivity, it’s important to use the lowest effective dose

Side Effects:

Biso-Bloc is usually well tolerated. It may rarely cause fatigue, dizziness, mild headache, muscle and joint ache, and coldness of extremities. Occasional gastrointestinal side effects may occur such as nausea, diarrhoea, and sleep disturbances.


Untreated cardiac failure, cardiogenic shock, sinoatrial block, second or third degree AV block, extreme hypotension, or severe asthma.

Drug Interactions:

The drug should not be combined with other beta-blocking agents. Biso-Bloc may potentiate the effect of other concurrently administered antihypertensive drugs such as reserpine, α-methyldopa, and clonidine. The therapy with clonidine must be discontinued for several days before bisoprolol administration. The drug should be used with care with myocardial depressants, inhibitors of AV conduction such as calcium antagonist (e.g. verapamil, diltiazem), or class I anti-arrhythmic (such as disopyramide). Rifampicin can reduce the elimination half life of the drug. The effects of insulin or oral hypoglycaemic agents may be potentiated when used concurrently with the drug. Particular care should be taken when anesthetic agents which depress myocardial function (such as ether, cyclopropane, and trichloroethylene).


  • Care must be taken when exercising, since the drug reduces heart rate.
  • It must be used with care in peripheral circulatory disturbances such as Raynaud's phenomenon.
  • It may be used with caution in patients with chronic obstructive air ways disease or asthma. If bronchospasm occurs, it can be reversed by using bronchodilators (such as salbutamol).
  • It should be used with caution in diabetic patients, since the symptoms of hypoglycaemia may be masked.
  • β-blockade may mask clinical signs of hyperthyroidism, such as tachycardia.

Use in Pregnancy or Lactation:

Like other β-blockers benefits of use during pregnancy should be weighed against the possible risk. Caution should be exercised for use during lactation.


Domina Pharmaceuticals
P.O. Box : 9622
Damascus - Syria


Phone: +963 (11) 33 192 32
Phone: +963 (11) 33 201 04
Mobile: +963 (932) 993 304 159
Mobile: +963 (932) 993 366 254